Aging is different than previously thought. New discovery
" Based on aging-related protein changes, we developed tissue-specific age clocks and characterized aging trajectories at the organ level. Time-of-flight analysis revealed that the aging process reaches a critical point around age 50, and blood vessels are a tissue that ages early and is clearly susceptible to the passage of time," emphasize the researchers from the Chinese Academy of Sciences.
The study authors compared their findings with a database of diseases and their associated genes. They found that the expression of 48 disease-related proteins increased with age. These included cardiovascular disease, tissue fibrosis, fatty liver disease, and liver-related cancers.
Researchers also conducted tests on mice, confirming that an aging-associated protein isolated from the aorta, when injected into young mice, reduced their physical performance, endurance, and coordination. Markers of aging in blood vessels were also visible.
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According to sciencealert.com, previous research has indicated two different peaks in aging, occurring around age 44 and then around age 60. Recent research suggests that human aging is a multi-stage process involving various systems. Discovering how aging affects specific organs could help develop medical procedures that impact this process.
“Our study is poised to construct a comprehensive, multi-tissue protein atlas spanning 50 years of the entire human aging process, elucidating the mechanisms behind protein imbalances in aging organs and revealing both universal and tissue-specific patterns of aging,” the study authors conclude.
